The protective effect of vitamin A on Concor induced structural changes of the liver and kidney in adult rats

Abstract Concor is a beta-blocker drug used to treat high blood pressure, acute coronary syndrome, and control the rapid pulse of heart such as atrial fibrillation. Some its adverse effects include hepatitis, increased triglycerides liver enzymes. Monitoring kidney functions in patients with hepatic or renal impairment who are taking concor recommended. The current study was undertaken define whether vitamin A could improve structural changes kidneys. 24 rats were grouped into following. first group control. second given Vitamin (5000 IU). Group 3: at daily dose 0.9 mg/kg B. wt. IV: received (0.9 wt.) IU) orally. After 4 weeks, treated 3 exhibited degenerative alterations glomeruli, enlargement Bowman’s space epithelium proximal tubules showed vacuolar degeneration necrosis. Liver sections necrosis hepatocytes, congestion central vein, dilation sinusoids inflammatory cell infiltration. mild expansion tubular epithelium, normal architecture Kupffer cells. From this study, we concluded that induces these improved by administration.